Guide Kinase Inhibitor Drugs (Wiley Series in Drug Discovery and Development)

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Since the discovery of protein kinase activity in , the field of protein kinase drug discovery has advanced dramatically. With the ongoing clinical success of.
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Ann Intern Med ; 73 : Actvity of a new glycosidic lignan derivative VP related to podophyllotoxin in experimental tumors. Eur J Cancer ; 9 : Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N Engl J Med ; : Plant antitumor agents. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.

J Am Chem Soc ; 93 : Plant anti-tumor agents: I.

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The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J Am Chem Soc ; 88 : CrossRef Google Scholar. Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and IV ovarian cancer. N Engl J Med ; : 1 Bertino JR. Irinotecan for colorectal cancer. Semin Oncol ; 24 : S18 -S Topotecan, an active drug in the second-line treatment of epithelial ovarian cancer. J Clin Oncol ; 14 : Structures of harringtonine, isoharringtonine, and homoharringtonine.

Tetrahydron Lett ; 11 : Treatment of myelogenous leukemia: current status and investigational options. Blood ; 87 : Rehm S, Devor DE. J Cancer Res Clin Oncol ; : 41 Phase I and pharmacological study of the pulmonary cytotoxin 4-ipomeanol on a single dose schedule in lung cancer patients: hepatotoxicity is dose limiting in humans. Cancer Res ; 53 : Cragg G, Suffness M.

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Metabolism of plant-derived anti-cancer agents. Pharmacol Ther ; 37 : Antitumor activity, pharmacology, and toxicity of ellipticines, ellipticinium and 9-hydroxy-derivatives: preliminary clinical trials of 2-methylhydroxy-ellipticinium NSC Recent Res Cancer Res ; 74 : The structure of rohutukine, the main alkaloid of Amoora rohituka syn. Aphanamixis polystachya Maliaceae. Tetrahydron ; 8 : Flavopiridol L, NSC , a new kinase inhibitor for tumor therapy. Int J Oncol ; 9 : Potent inhibition of cdc2 kinase activity by the flavonoid L Biochem Biophys Res Commun ; : Alteration of the phosphorylation state of p32 cdc2 kinase by the flavone L in breast carcinoma cells.

Biochem Pharmacol ; 46 : Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms. J Clin Oncol ; 16 : Clinical trials referral resource. Clinical trials of flavopiridol. Oncology Huntingt ; 12 : Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L J Natl Cancer Inst ; 84 : Schultes RE.

Kinase Inhibitor Drugs (Wiley Series in Drug Discovery and Development)

Amazonian ethnobotany and the search for new drugs. Balick MJ. Ethnobotany and the identification of therapeutic agents from the rainforest. Summary of the workshop on drug development, biologic diversity, and economic growth. J Natl Cancer Inst ; 83 : Coral reefs, forests, and thermal vents: the worldwide exploration of nature for novel antitumor agents. Semin Oncol ; 24 : Hartwell JL. Types of anti-cancer agents isolated from plants. Cancer Treat Rep ; 60 : Plants used against cancer. A survey. Lawrence, CA: Quarterman Publications, Huxtable RJ.

The pharmacology of extinction.

J Ethnopharmacol ; 37 : 1 Han R. Recent progress in the study of anti-cancer drugs originating from plants and traditional medicines in China. Chin Med Sci J ; 9 : 61 Powis G. Anti-cancer drugs: antimetabolite metabolism and natural anti-cancer agents. Int Encycl Pharmacol Ther ; : 1 Immunomodulatory and anti-tumour polysaccharides from medicinal plants. J Int Med Res ; 22 : Moerman DE. Kapoor LD. CRC handbook of Ayurvedic medicinal plants.

Tunon H, Bruhn JG. Drugs in ancient texts. Nature ; : Plantas da medicina popular no Rio Grande do Sul.

Moreira F. Plantas que curam. Komoda Y, Kishi T. Maytansinoids Chapter New York: Academic Press, Suffness M, Cordell GA. Antitumor alkaloids Chapter I. In: Brossi A, ed.

Introduction Strategies in Drug Discovery and Evaluation | SpringerLink

The Alkaloids. Orlando: Academic Press, Decreased mortality of Norman murine sarcoma in mice treated with the immunomodulator, acemannan. Mol Biother ; 3 : 79 Kaplan IW. Condylomata acuminata. New Orleans Med Surg J ; 94 : Evaluation of the genotoxic activity and acute toxicity of Euphorbia splendens latex, a molluscicide for the control of schistosomiasis.

Braz J Med Biol Res ; 24 : Evaluation of the mutagenicity of the molluscicidal latex of Christ's Crown Euphorbia milii var. Mutat Res ; : 15 Antitumor agents, Kansuiphorins A and B, two novel antileukemic diterpene esters from Euphorbia kansui. J Nat Prod ; 54 : Selectively cytotoxic diterpenes from Euphorbia poisonii. J Med Chem ; 39 : Isogravacridonchlorine: a potent and direct acting frameshift mutagen from the roots of Ruta graveolens. Planta Med ; 57 : 59 Inhibitory effects of furocoumarins in Salmonella typhimurium TA98 on the mutagenicity of dictamnine and rutacridone, promutagens from Ruta graveolens.

Mutagenesis ; 6 : Structures and cytotoxic activity relationship of casearins, new clerodane diterpenes from Casearia sylvestris Sw. Chem Pharm Bull Tokyo ; 39 : New antitumor principles, casearins A-F, for Casearia sylvestris Sw. Chem Pharm Bull Tokyo ; 38 : Inhibition of topoisomerase I function by nitidine and fagaronine.

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  • Protein Kinases as Drug Targets.
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Chem Res Toxicol ; 6 : Identification of novel topoisomerase I inhibitors. Proc Am Assoc Cancer Res ; 35 : Chelerythrine and sanguinarine alkaloids induce membrane translocation and irreversible inactivation of protein kinase C by modifying thiol residues. Wolff J, Knipling L. Antimicrotubule properties of benzophenanthridine alkaloids. Biochemistry ; 32 : Ringel I, Horwitz SB. Studies with RP taxotere : a semisynthetic analogue of taxol.

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Potential antitumor agents. Physalin B and 25,epidihydrophysalin C from Witheringia coccoloboides. J Nat Prod ; 44 : Inhibitory effects of physalin B and physalin F on various human leukemia cells in vitro.